Biotechnology is an area of science that is concerned with the industrialized production of biopharmaceuticals and biological utilization of genetically modified microbes. Modern biotechnology is changing the manner of growing plants and animals aiming to offer opportunities in improving nutritional content, product quality and economic value. Biotechnology has four most important areas of application such as health care, agriculture, industrial processes and wildlife management and conservation.
Genetic engineering in biotechnology stimulated hopes for both therapeutic proteins, drugs and biological organisms themselves, such as seeds, pesticides, engineered yeasts, and modified human cells for treating genetic diseases. The field of genetic engineering remains a heated topic of discussion in today’s society with the advent of gene therapy, stem cell research, cloning, and genetically-modified food.
Biotechnology is the applied science and has made advances in two major areas, molecular biology and production of industrially important bio-chemical. The scientists are now diverting themselves toward biotechnological companies; this has caused the development of many biotechnological industries.
In USA alone more than 225 companies have been established and successfully working, like Biogen, Genentech, Hybritech, etc. In world, USA, Japan, and many countries of Europe are leaders in biotechnological researchers encouraged by industrialists.
Biotechnology in Agriculture.
Food and Bioprocess Technology.
Plant and Environment.
Biotechnology in Healthcare Industry.
Microbial and Biochemical Technology.
Metabolomics and Genomics Research.
Bioremediation and Biodegradation
Systems and Synthetic Biotechnology
Biomass and Bioenergy.
Bio-Safety and Bioethics.
Biotechnology and its Applications.
Frontiers in Biotechnology.
Current Scenario in Biotechnology.
Target Audience will be personnel from both industrial and academic fields which include; CEOs, COOs, Directors, Vice Presidents, Co-directors, Biotechnologists, Managing Directors, Industry Safety Officers, Environmental & Plant Scientists, Doctorates, Professors, Post Doctorate Fellows, Vendors of Consumer Products/ Managers, Pharmaceutical Scientists, Students from the related fields.
Benefits of joining the Conference:
Citations International affords a tremendous opportunity to join in this forum to utilize the expertise and novelties that expands the participant’s views in the field of Biotechnology. We also aim to bring together front-line experts from multidisciplinary research and application areas to join this conference, to discuss the ongoing Research and Development efforts in the field of Biotechnology.
Biotechnology Organizations in Dubai:
New Green World.
Thermo Fisher Scientific.
PSN Life sciences International.
Dr. Brill & Partners Institute for Hygiene and Microbiology.
Cryo Save Arabia.
Access Value Healthcare Solutions.
LS Life Scientific Medical Laboratory.
Methyl C1 Beads.
Biotechnology in Agriculture
Biotechnology has been practiced for a long time, as people have sought to improve agriculturally important organisms by selection and breeding. An example of traditional agricultural biotechnology is the development of disease-resistant wheat varieties by cross-breeding different wheat types until the desired disease resistance was present in a resulting new variety. Genetic engineering technologies can help to improve health conditions in less developed countries. Genetic engineering can result in improved keeping properties to make transport of fresh produce easier, giving consumers access to nutritionally valuable whole foods and preventing decay, damage, and loss of nutrients. Benefits of Agriculture Biotechnology include increased crop productivity, Enhanced crop protection, Improvements in food processing, improved nutritional value, Environmental benefits, Better flavor and Fresher produce.
Food and Bioprocess Technology
Biotechnology as applied to food processing in most developing countries makes use of microbial inoculants to enhance properties such as the taste, aroma, shelf-life, texture and nutritional value of foods. These high value products are increasingly produced in more technologically advanced developing countries for use in their food and non-food processing applications.
A range of technologies is applied at different levels and scales of operation in food processing across the developing world. Conventional or “low-input” food processing technologies include drying, fermentation, salting, and various forms of cooking, including roasting, frying, smoking, steaming, and oven baking. Food processing is a process by which non-palatable and easily perishable raw materials are converted to edible and potable foods and beverages, which have a longer shelf life.
Bio-fortification is a method of crops to increase their nutritional value. This can be done either through conventional selective breeding, or through genetic engineering. Bio-fortification differs from ordinary fortification because it focuses on making plant foods more nutritious as the plants are growing, rather than having nutrients added to the foods when they are being processed. This is an improvement on ordinary fortification when it comes to providing nutrients for the rural poor, who rarely have access to commercially fortified foods.
Golden rice is an example of a GM crop developed for its nutritional value. Golden rice contains genes from the soil bacterium ‘Erwinia’ and either maize or daffodil plants, and contains increased levels of ‘Beta carotene’ which can be converted by the body into vitamin A. This can help alleviate symptoms of Vitamin A deficiency. Researchers at the University of Warwick have been looking for ways to boost the low selenium levels in British grains, and have been working to develop a grain to be used in making bread biofortified with selenium as selenium helps to prevent prostrate cancer. Efforts are on to identify exotic and indigenously identified candidate genes to be exploited to enhance the level of essential nutrients such as iron, zinc, vitamins, balanced proteins etc., in major crops and in specific pulse and oilseed crops.
Pharmaceutical Biotechnology is the science that covers all technologies required for producing, manufacturing and registration of biological drugs. Pharmaceutical Biotechnology is an increasingly important area of science and technology. It contributes in design and delivery of new therapeutic drugs, diagnostic agents for medical tests, and in gene therapy for correcting the medical symptoms of hereditary diseases. The Pharmaceutical Biotechnology is widely spread, ranging from many ethical issues to changes in healthcare practices and a significant contribution to the development of national economy. Biopharmaceuticals consists of large biological molecules which are proteins. They target the underlying mechanisms and pathways of a disease or ailment; it is a relatively young industry. They can deal with targets in humans that are not accessible with traditional medicines.
Marine Biotechnology and Aquaculture have been the subject of great importance not only because of the sustainable utilization of their resources to feed the billion people of the world but also for the future challenges for discovery of new products and process development of economic importance through its treasure recognition and diversification. Apart from contributing to high quality and healthy food (aquaculture), nutraceuticals and medicinal products (anti-cancer and antimicrobials), this sector is expected to contribute to sustainable alternative source of energy (biofuel from microalgae) and environmental health. The potential for the contribution of Marine Biotechnology is, therefore, even more relevant now than it was ten years ago and a sound strategy for its development in India is urgently needed to allow this potential to be realized. Marine Biotechnology is capable of making an important contribution towards meeting impending challenges like a sustainable supply of food and energy and human health. Marine Biotechnology is providing many new solutions to Industry and Agriculture, including environmentally friendly pesticides and salt-resistant enzymes that are helpful in many industrial applications.
Molecular biotechnology is the use of laboratory techniques to study and modify nucleic acids and proteins for applications in areas such as human and animal health, agriculture, and the environment. Molecular biotechnology results from the convergence of many areas of research, such as molecular biology, microbiology, biochemistry, immunology, genetics, and cell biology. It is an exciting field fueled by the ability to transfer genetic information between organisms with the goal of understanding important biological processes or creating a useful product.
The key drivers for molecular biology enzymes, kits and reagents market are the rising R&D expenditure by the pharmaceutical and biotech companies, and increasing public funding for life science research. The World Health Organization estimates that the total aged population may rise from 605 million in 2000 (11% of the global population) to 2 billion by 2050, accounting for 22% of the global population.
Plant and Environment
The Biotechnology that is applied and used to study the natural environment. Environmental biotechnology could also imply that one try to harness biological process for commercial uses and exploitation. Environmental biotechnology as "the development, use and regulation of biological systems for remediation of contaminated environments and for environment-friendly processes”. Environmental biotechnology can simply be described as "the optimal use of nature, in the form of plants, animals, bacteria, fungi and algae, to produce renewable energy, food and nutrients in a synergistic integrated cycle of profit making processes where the waste of each process becomes the feedstock for another process".
U.S. sales of environmental biotechnology products was valued at $241.2 million in 2012. This is expected to increase at a total compound annual growth rate (CAGR) of 7.9%, with 2013 sales of $261.9 million, rising to $382.3 million in 2018.
Green biotechnology is defined as the application of biological techniques to plants with the aim of improving the nutritional quality, quantity and production economics. The most recent application of biotechnology in respect to this area is genetic modification (GM), also known as genetic engineering, genetic manipulation, gene technology and/or recombinant DNA technology. The collective term “Genetically Modified Organisms” (GMO) is used frequently in regulatory documents and in the scientific literatures to describe plants, animals and microorganisms, which had DNA introduced into them by means of genetic engineering.
Nanotechnology is a novel scientific approach that involves materials and equipments capable of manipulating physical as well as chemical properties of a substance at molecular levels. On the other hand, biotechnology uses the knowledge and techniques of biology to manipulate molecular, genetic and cellular processes to develop products and services and is used in diverse fields from medicine to agriculture. Nanobiotechnology is considered to be the unique fusion of biotechnology and nanotechnology by which classical micro-technology can be merged to a molecular biological approach in real. Through this methodology, atomic or molecular grade machines can be made by mimicking or incorporating biological systems, or by building tiny tools to study or modulate diverse properties of a biological system on molecular basis. Nanobiotechnology may, therefore, ease many avenues of life sciences by integrating cutting-edge applications of information technology & nanotechnology into contemporary biological issues. This technology has potential to remove obvious boundaries between biology, physics and chemistry to some extent, and shape up our current ideas and understanding. For this reason, many new challenges and directions may also arise in education, research & diagnostics in parallel by the extensive use of nanobiotechnology with the passage of time.
Biotechnology in Healthcare Industry
Biotechnology in Healthcare is the maintenance or improvement of health via the diagnosis, treatment, and prevention of disease, illness, injury, and other physical and mental impairments in human beings. Health care is delivered by health professionals allied health professions, chiropractic, physicians, physician associates, dentistry, midwifery, nursing, medicine, optometry, pharmacy, psychology, and other health professions. It includes the work done in providing primary care, secondary care, and tertiary care, as well as in public health.
Animal biotechnology is the use of science and engineering to modify living organisms. The goal is to make products, to improve animals and to develop microorganisms for specific agricultural uses. Examples of animal biotechnology include creating transgenic animals (animals with one or more genes introduced by human intervention), using gene knock out technology to make animals with a specific inactivated gene and producing nearly identical animals by somatic cell nuclear transfer (or cloning).
Animal biotechnology has many potential uses. Since the early 1980s, transgenic animals have been created with increased growth rates, enhanced lean muscle mass, enhanced resistance to disease or improved use of dietary phosphorous to lessen the environmental impacts of animal manure. Transgenic poultry, swine, goats and cattle that generate large quantities of human proteins in eggs, milk, blood or urine also have been produced, with the goal of using these products as human pharmaceuticals. Human pharmaceutical proteins include enzymes, clotting factors, albumin and antibodies. The major factor limiting the widespread use of transgenic animals in agricultural production systems is their relatively inefficient production rate (a success rate of less than 10 percent).
Industrial biotechnology is the application of biotechnology for industrial purposes, including industrial fermentation. The practice of using cells such as micro-organisms, or components of cells like enzymes, to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels. Industrial Biotechnology offers a premier forum bridging basic research and R&D with later-stage commercialization for sustainable bio based industrial and environmental applications.
An increasing number of chemicals and materials, like base chemicals, polymers, industrial catalysts, enzymes and detergents are produced using biotechnology. In 2010, the sales of industrial chemicals created using biotechnology in at least one step of the production process equaled €92bn globally, and this is expected to increase to €228bn by 2015.
Microbial and Biochemical Technology
Microorganisms have been exploited for their specific biochemical and physiological properties from the earliest times for baking, brewing, and food preservation and more recently for producing antibiotics, solvents, amino acids, feed supplements, and chemical feedstuffs. Over time, there has been continuous selection by scientists of special strains of microorganisms, based on their efficiency to perform a desired function. Progress, however, has been slow, often difficult to explain, and hard to repeat.
Recent developments in molecular biology and genetic engineering could provide novel solutions to long-standing problems. Over the past decade, scientists have developed the techniques to move a gene from one organism to another, based on discoveries of how cells store, duplicate, and transfer genetic information.
Metabolomics and Genomics Research
Genomics is the new science that deals with the discovery and noting of all the sequences in the entire genome of a particular organism. The genome can be defined as the complete set of genes inside a cell. Genomics, is, therefore, the study of the genetic make-up of organisms.
The metabolome refers to the complete set of low molecular weight compounds in a sample. These compounds are the substrates and by-products of enzymatic reactions and have a direct effect on the phenotype of the cell. Thus, metabolomics aims at determining a sample’s profile of these compounds at a specified time under specific environmental conditions. Metabolomics can be used to determine differences between the levels of thousands of molecules between a healthy and diseased plant. The technology can also be used to determine the nutritional difference between traditional and genetically modified crops, and in identifying plant defense metabolites.
Medical biotechnology refers to a medicinal or diagnostic product or a vaccine that consists of or has been produced in living organisms and may be manufactured via recombinant. Medical Biotechnology has a tremendous impact on meeting the needs of patients and their families as it not only encompasses medicines and diagnostics that are manufactured using a biotechnological process, but also gene and cell therapies and tissue engineered products. Today, the majority of innovative medicines, whether manufactured using biotechnology or via a chemical synthesis like a traditional small molecule medicine, as well as many diagnostic products, are made available by applying modern biotechnology in their development and manufacturing.
In the field of medicine, biotechnology has made an impressive impact in the area of drug production, gene therapy, pharmagenomics and genetic testing. Gene therapy is the insertion, alteration, or removal of genes with in an individual’s cells and biological tissue to treat a disease.
Petroleum refining is traditionally based on the use of physicochemical processes such as distillation and chemical catalysis that operate under high temperatures and pressures conditions, which are energy intensive and costly. Biotechnology has become an important tool for providing new approaches in petroleum industry during oil production, refining and processing as well as managing environmentally safe pollutant remediation and disposal practices. Earlier biotechnology applications in the petroleum industry were limited to microbial enhanced oil recovery, applications of bioremediation to contaminated marine shorelines and soils. The potential role of bioprocess technology in this industry has now expanded further into the areas of bio-refining and upgrading of fuels, production of fine chemicals, control of souring during production and air VOC bio-filtration.
Petroleum exploration & production deals with the production of hydrocarbons from subsurface reservoirs of earth with the help of petroleum geology, drilling, reservoir simulation, reservoir engineering, completions and oil and gas facilities engineering and many other disciplines. The produced hydrocarbons are available in the form of crude oil or natural gas. Environmental engineering is an application of Science and Engineering integration, which can be used to improve the quality of environmental aspects like air, water, land, etc.
Biotechnology, the application of chemical, physical and engineering principles and techniques to biological systems, offers potential for significant benefits in medicine and agriculture. The new biotechnologies that are being applied in domestic farm animal production and in research on reproduction are nothing short of amazing. Artificial insemination with frozen semen, introduced in the 1950's, permits high quality bulls to be bred to cattle throughout the world.
More recently, technologies related to the early embryo have emerged. Embryos may be split at early stages to produce identical twins. Production of two identical can be very valuable to research scientists as well as doubling the number of embryos for transfer from a genetically valuable mating. Another technique is that of freezing embryos for later transfer to surrogate mothers who may be located anywhere in the world. This ability is very valuable when an excess of embryos are produced for the available recipients. These techniques can be used to both increase genetic gain, by extending the selection pressure, and provide a broader genetic base, by freezing large stocks of genetic material.
Bioremediation and Biodegradation
The elimination of a wide range of pollutants and wastes from the environment is an absolute requirement to promote a sustainable development of our society with low environmental impact. Biological processes play a major role in the removal of contaminants and they take advantage of the astonishing catabolic versatility of microorganisms to degrade/convert such compounds.
Systems and Synthetic Biotechnology
Systems and Synthetic Biotechnology is a relatively new field in biomedical research. It focuses on engineering new or modified signaling proteins to create desired signaling pathways in the cell. Every living cell is an extremely complex machine expressing thousands of different proteins. Due to superb regulation, many cells, such as photoreceptors and other neurons in vertebrates, can live for decades. Cells can also self-reproduce by division, where both daughter cells are perfectly viable. Natural selection spent hundreds of millions of year to achieve this perfection. Due to elucidation of the intricacies of cellular regulatory mechanisms we can now play evolution on our time scale: re-design proteins and signaling pathways to achieve our ends. Systems and Synthetic Biology is a novel field that finds its origin at the intersection of biology and engineering. It involves designing and construction of biological systems or devices that can be applied in varied domains to get specified results. It’s a multidisciplinary effort made by scientists to understand the functioning of biological organisms, cells & genes and implementation of artificial genetic processes to give specific characteristics to an organism. It can even be used to develop a completely new biological system.
Biomass and Bioenergy
Bioenergy is the chemical energy contained in organic matter (biomass) which can be converted into energy forms that we can use directly, such as electricity, heat and liquid fuel. Biomass is any organic matter of recently living plant or animal origin. Unlike coal, the organic matter is not fossilized. Traditionally mainly woody biomass has been used for bioenergy, however more recent technologies have expanded the potential resources to those such as agricultural residues, oilseeds and algae. These advanced bioenergy technologies allow for the sustainable development of the bioenergy industry, without competing with the traditional agricultural industry for land and resources. Bioenergy plants can range from small domestic heating systems to multi-megawatt industrial plants requiring hundreds of thousands of tons of biomass fuel each year. A variety of technologies exists to release and use the energy contained in biomass. They range from combustion technologies that are well proven and widely used around the world for generating electricity generation, to emerging technologies that convert biomass into liquid fuels for road, sea and air transport.
Bio-Safety and Bioethics
Biosafety is the prevention of large-scale loss of biological integrity, focusing both on ecology and human health. These prevention mechanisms include conduction of regular reviews of the biosafety in laboratory settings, as well as strict guidelines to follow. Biosafety is used to protect from harmful incidents. Many laboratories handling Biohazards employ an ongoing risk management assessment and enforcement process for biosafety. Failures to follow such protocols can lead to increased risk of exposure to Biohazards or Pathogen. Human error and poor technique contribute to unnecessary exposure and compromise the best safeguards set into place for protection.
Biotechnology and its Applications
The applications of biotechnology include therapeutics, diagnostics and genetically modified crops for agriculture, processed food, bioremediation, waste treatment, and energy production.
Three critical research areas of biotechnology are;
Frontiers in Biotechnology
Biotechnology is an innovative science in which living systems and organisms are used to develop new and useful products, ranging from healthcare products to seeds. The field of Biotechnology is growing rapidly making tremendous impacts in Medical/Health Care, Food & Agriculture. The Global Biotechnology industry is in the growth phase of its economic life cycle. Over the five years to 2014, revenue and industry value added (IVA) growth have outpaced world GDP growth.
The Frontiers in Biotechnology track will cover current technological aspects that aim at obtaining products with scientific, industrial, health and agricultural applications, from organisms with increasing levels of complexity from bacteria, yeast, plants, animal cells and virus. With the lectures and demonstrations on stem cell therapy, Embryo transfer technology, next generation sequencing, Drug discovery, biotechnology in food and dairy, etc. The participants are expected to acquire knowledge in techniques and methodologies used in Biotechnology.
Current Scenario in Biotechnology
Due to multidisciplinary nature of the field of biotechnology, a wide range of different branches of science have made significant contributions to the fast development of this field. Some of these disciplines are biochemical engineering, physiology, biochemistry, food science, material science, bioinformatics immunology, molecular biology, chemical engineering etc.
Biotechnology is also improving the lives of people around the world. The most famous example is the production of insulin. Before 1982, insulin required for the treatment of diabetes was obtained from pig and cow pancreas. The procedure used was very costly, tedious and often lead to complications while using the animal insulin. Using biotechnological tools, the human gene for insulin was isolated, cloned and expressed in microorganisms and large scale production of insulin started. Insulin was the first pharmaceutical product of recombinant DNA technology that was approved for human use. Millions of diabetic patients’ were benefited by the biotechnological production of insulin.
Biotechnology also has affected economy in a positive way due to the creation and growth of small business, generation of new jobs. Agricultural biotechnology has reduced our dependency on pesticides. Bioremediation technologies are being used to clean our environment by removing toxic substances from contaminated ground water and soils. The biotechnology has contributed in health services, agricultural sciences (improved crop yield, food quality, improved health of livestock and farm animals), and in environmental monitoring, pollution control.
Modern biotechnology products started coming to the market in the late 1980s. Today, about 60% of the biotechnology products in the market are healthcare products and 21% are products used in agriculture and animal husbandry. A considerable amount of efforts in research are on, to use and extract benefit from this interesting and upcoming field for the betterment of human life and the environment.
Many biochemical companies such as National Pituitary Agency (U.S.A), GeneTech Co. (U.S.A), Biogen (Switzerland), E. Lilly (U.S.A) are involved in the production of biotechnological products using genetic engineering techniques. Many countries have developed collaborative networks and relationships on various aspects of biotechnology such as” International Cell Research Organisation “(ICRO), “ Regional Microbiology Network for South-East Asia” (supported by Japan and UNESCO), Microbiological Resource Centres (MICRCENS, supported by UNESCO).
Biotechnology - Market Analysis:
There is almost no discipline among the science subjects that has not contributed either directly or indirectly to the growth of biotech. These branches are the roots of the biotech tree.
There are several methods, techniques or procedures that are collectively called as biotechnological tools that have been developed for transforming the scientific foundations into biotechnological applications.
The product or the fruits of this biotechnological tree has wide range of applications such as in the medical and health sciences, agriculture, environment etc.
The key areas of research in biotechnology can be summarized as following:
The global market for bioengineered protein drugs is expected to reach $228.4 billion by 2021 from $172.5 billion in 2016, rising at a compound annual growth rate (CAGR) of 5.8% from 2016 through 2021. The industrial enzymes report by BCC Research analyzes present and future strategies for detergent enzymes, technical enzymes, food enzymes and animal feed enzymes. The global market for sample preparation in genomics, proteomics and epigenomics reached $5.2 billion in 2015. The market should reach $5.6 billion in 2016 and $7.7 billion by 2021, growing at a compound annual growth rate (CAGR) of 6.5% from 2016 to 2021. The global market for biobanking technologies was valued at $186.3 billion in 2015. This market is expected to increase from $198.2 billion in 2016 to $240.2 billion in 2021 at a compound annual growth rate (CAGR) of 3.9% for 2016-2021. The global market for bioprinting reached $263.8 million in 2015. The market should reach $295 million in 2016 and $1.8 billion by 2021, growing at a compound annual growth rate (CAGR) of 43.9% from 2016 to 2021. The global market for microbiology technology, equipment and consumables market reached $9.8 billion revenue in 2015. The market should reach nearly $12.3 billion by 2020, increasing at a compound annual growth rate (CAGR) of 4.6% from 2015 to 2020.
The top 10 cellular analysis market is expected to reach USD 41.34 Billion by 2021 from USD 28.66 Billion in 2016, at a CAGR of 7.6% during the forecast period. Cellular analysis is used for cell identification, cell interaction, cell viability, cell proliferation, cell structure study, cell signaling/cell transduction, target identification & validation, cell counting, and quality control. Currently, cellular analysis technologies are used in various phases of the drug discovery process, cancer diagnosis (oncology), blood cell analysis, toxicity testing, personalized medicine, pathogen testing, and other applications.
The global cell sorting market is projected to reach USD 247.4 Million by 2021, at a CAGR of 7.0% in the forecast period (2016–2021). Factors such as technological advancements in cell sorters, rising funding and investments for development of technologically advanced cell sorters, and growing adoption of cell sorting techniques in research activities are driving the growth of this market. The market is further driven by factors such as the growing prevalence of HIV/AIDS and cancer, expanding pharmaceutical and biotechnology industries, and launch of specific reagents for specific applications. However, factors such as the high cost of instruments and lack of awareness & technical knowledge regarding the use of cell sorters are hampering the growth of this market.
The high-throughput screening market (HTS) is estimated to grow at a CAGR of 7.8% from 2016 to 2021 to reach USD 18.83 Billion by 2021. Market growth can be attributed to the growing adoption of open innovative models in the pharmaceutical and biotechnology industry and technological advancements like automation and miniaturization, increasing R&D spending and rising government funding. Emerging markets and growing research activities in toxicology and stem cells provide significant growth opportunities for the market.
The global oxidative stress assays market is expected to reach $736.85 Million by 2020 from $452.36 Million in 2015, at a CAGR of 10.25% between 2015 and 2020. Factors such as rapid growth in the biopharmaceutical industry, strong trend of R&D investments in biotechnology and pharmaceutical industries, technological advancements like high-content screening for drug discovery, and government funding for life science research are driving the growth of the oxidative stress assays market. On the other hand, high cost of instruments and dearth of trained manpower for new and emerging technologies are the major factors restraining the growth of this market.