Organizing Committee


Dr. Apurba K Bhattacharjee

Computational Chemistry

Georgetown University

USA

Apurba K. Bhattacharjee graduated with a Ph.D. degree in chemistry from the North Eastern Hill University, India in 1983. After completing postdoctoral research was at the “Institut de Topologie et de Dynamique des Systemes de l'Universite Paris 7, Paris, France with Professor J.-E. Dubois for three years, he joined Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD (USA). He served in the institute for over twenty years starting as a Senior Research Associate Fellow under National Research Council (USA) and retired as the Chief Molecular Modeler of WRAIR in early 2012. Currently, he is an Adjunct Associate Professor at the Department of Microbiology and Immunology at the School of Medicine, Georgetown University Medical Center, Georgetown University, Washington, D.C, USA. His research is in the field of computer assisted drug design and discovery (CADDD), particularly in the application of molecular electrostatic potentials (MEPs) in the design of novel therapeutics, specifically the “interaction pharmacophores” to elucidate biological activities. The goal of his research is to develop in silico3D pharmacophore models from known biologically active compounds and use the models for virtual screening of compound databases to identify new active compounds. At WRAIR, his research supported the design and discovery of compounds against malaria, leishmaniasis, mosquitos (repellents) and counter agents for chemical and biological threat agents. His current research involves design and discovery of antiviral therapeutics against DENV, ZIKV and WNV. Very recently, his computer aided discovery research resulted in the discovery of 3 anti-Zika compounds (Antiviral Research 2016, in press). He also has over 25 years of experience in teaching and seminars for undergraduate and postgraduate students in India and Georgetown University. He has authored and coauthored 125 peer reviewed publications including four book chapters and 5 patents.


Dr. Md Maniruzzaman

Pharmaceutical Formulations/ Particle Engineering (Chemistry)

University of Sussex

United Kingdom

Dr Maniruzzaman is currently a Research Fellow at University of Sussex. Prior to this, he was appointed as an Industrial Research Fellow at the University of Greenwich, funded by Fuji Chemical Industry Co., Ltd., Japan. He studied and obtained a B.Sc Hon’s with first class in Pharmaceutical Sciences in 2009 and was recognized as the best international student at undergraduate level. In the same year, he was awarded a prestigious ORSAS bursary followed by University bursary to pursue a PhD in formulations of oral solid dosage forms and process engineering at the University of Greenwich. Dr Maniruzzaman obtained a PhD with no corrections (RDC/12/M-3/14, UoG) with two accompanying awards including the Vice Chancellor’s Award in 2013 for the outstanding performance in his doctoral research. He is a pharmaceutical scientist member (SRPharmS) of the Royal Pharmaceutical Society, UK and served as Chair of UoG-AAPS Chapter. During the past years of research, he has attended more than 10 international conferences and delivered more than 20 podium presentations and invited lectures on different novel formulation aspects which have motivated him to publish more than 40 peer reviewed articles in well recognised international journals including UK patents (pending) and edited books. He also contributed 10 book chapters in various books. He has recently co-edited a special issue, "Continuous Manufacturing and Process Analytical Tools" in International Journal of Pharmaceutics and secured three substantial grants as the PI.


Dr. Yin Luo

Physical Chemistry, Chemical Biology, Biochemistry

Pfizer

USA

Biophysical Characterization for Product Comparability

Drug manufacturers must demonstrate the comparability of their products after process and formulation changes to ensure similar quality, safety, and efficacy. Biosimilars also require evaluation of their equivalency to the innovators' products. By complementing traditional biochemical methodologies, biophysical characterization, using a variety of methodologies, can enhance product knowledge in terms of higher order structure, molecular size distribution, and the properties of aggregates. This article presents three case studies that show the advantages of applying state-of-the-art biophysical techniques in comparability assessments.

Characterization and Analysis of Biopharmaceutical Proteins

Appropriate and complete analysis and characterization of biopharmaceutical proteins are important to the control of their safety, purity, potency, stability, and overall quality. This chapter reviews the methodologies that are used to characterize important attributes of biopharmaceutical proteins. The methods used to characterize the primary and higher-order structures are discussed, including techniques to determine protein sequence, posttranslational modifications, folding, and aggregation. Aberrant results for those attributes may raise quality issues. Methods for protein concentration are described, including amino acid analysis, intrinsic protein absorbance, and colorimetric methods. This is followed by the determination of impurities, both product-related and process-related, which may compromise the safety of the protein therapeutics. Various assays, including bioassays and non-cell based binding assays for determining the functional activity of proteins, which may be indicative of potency, are described in this chapter.


Prof.  Bahaa Jamal al- Din Muhammad

Pharmaceutical Organic Chemistry

Assiut University

Egypt​

A series of1,2,3-triazole derivatives bearing different chemical entitieswere prepared starting from2-(4-phenyl-1H-1,2,3-triazol-1-yl)acetohydrazide, compound2.The purity of all new compounds was checked by TLC and elucidationof their structures was confirmed byIR,1Hand13C NMRalong with High Resolution Mass Spectrometry (HRMS). All thetarget compounds were evaluatedfor their possible antimicrobial activity. Most of the tested compounds showed moderateto  good  antibacterial  activity  against  most  of  the  bacterial  strains  used  in  comparison  with  ciprofloxacin  as  a  referencedrug. The most active compounds were4a,9a,9b, and9f.Results of antifungal activity revealed that most of the testedcompounds showed a good antifungal activity in comparison to fluconazole as a reference drug. Compounds4a, 9c, 9dand9fwere the most active ones

A  new  series  of  4-methyl-7-methoxycoumarin  derivatives  linked  triazoles  and  oxadiazole  were  prepared  startingfrom 2-((4-methyl-2-oxo-2H-chromen-7-yl)oxy) acetohydrazide, compound4. The purity of all new compounds waschecked  by  TLC  and  elucidation  of  their  structureswas  confirmed  byIR,1Hand13C  NMRalong  with  HighResolution  Mass  Spectrometry  (HRMS).  All  the  target  compounds  were  evaluatedfor  their  possibleanti-inflammatory activities. The result showed that most of the tested compounds exhibited significant anti-inflammatoryactivity in comparison to indomethacin as a reference drug. The compound8lwas the most active one. Compounds6a,8g,8i,8kand8lwere  tested  for  their  analgesic effects in  comparison  to  indomethacin  as  a  reference  drug.Compounds6aand8ishowed activity comparable to the reference drug.Compounds6a,8dand8lwere examinedfor  their  effect  on  gastric  mucosa  and  showed  no  gastric  ulcerogenic  effect  at  dose  60  mg/Kg.  Moreover,  LD50ofcompounds6aand8lwere  determined; they  exhibited  no-toxic  effect  upto  240  and  300  mg/kg  (i.p.) respectively.Finally,  compounds7and8a-8jwere  evaluated  for  their  possible  antimicrobial  activity.  Most  of  the  testedcompounds  showed  moderate  to  good  antimicrobial  activity  against  most  of  the  strains  used  in  comparison  withciprofloxacin and fluconazole as reference drugs.


Prof. Mirza R. Baig

Dept of Clinical Pharmacy & Pharmacy Practice

Dubai Pharmacy College

UAE

Prof. Dr. Mirza R. Baig is currently working as a Head of Clinical Pharmacy department in Dubai Pharmacy College. He did his PhD in Clinical Pharmacy from University Science Malaysia (USM), Malaysia. He worked in Malaysia, India and has international teaching and research experience of about 16 years. He also worked as an Acting Dean in AIMST University, Malaysia. He published4 books related to Clinical Pharmacy and Pharmaceutical Care. He published more than 40 Research papers and articles in International Journals. He is in the editorial board in various international journals, including reviewer for couple of Elsevier journals. He supervised numerous master and PhD students for their research projects. He also reviewed several Master and PhD thesis for Indian and foreign universities as an external examiner.  He received many awards in his career, few of it as an Outstanding scientist by a research foundation in India 2016,Best Quality Research in 2016 in DUPHAT Dubai, Best oral presentation in Dubai 2015 & 2014, Young scientist award in Malaysia in 2013, Best presentation award in IPC 2003, in India. His area of research is Pharmacoepidemiology, Drug safety and efficacy, Drug Utilization Studies, Pharamcovigilance, and Public health.


Prof. Hassan Malekinejad

Pharmacology & Toxicology

Urmia University

Iran

Publications:

Acetaminophen toxicity up-regulates MRP2 expression in the liver of cats:

An old story with new vision

Skills and expertise

Inflammation, Mycotoxins, Gene Expression, Oxidative Stress, Gene Expression and Chromatin Biology, Inflammatory Biomarkers, Analytical Toxicology, Fish Toxicology, Zearalenone, Phytomedicine, aquatic molecular biology, Biotransformation, Plant Extracts, Malondialdehyde, Thiols, Nitric Oxide, Antioxidant Activity, Lipid Peroxidation, Antioxidants, NOS, Free Radical Scavengers, Reactive Oxygen Species, Oxidative Stress Biomarkers, Free Radicals, ROS, GSH, SOD, Redox Regulation, Free Radical Biology, CAT, Free Radical Biochemistry, GPx, Redox Signaling, Superoxide Detection, Peroxidases, FRAP, Hepatoprotective, Animal Feed, DPPH, Medicinal Plants, Rat Models, MDA, Metabolites, Histology, Hepatitis, Liver, Jurkat Cells, Serum, ALP, Cytotoxicity, Heat Stress, Broilers, Apoptosis, Biomarkers


Prof. Vladimir P. Torchilin

Pharmaceutical Sciences

Northeastern University

USA

Vladimir P. Torchilin is a University Distinguished Professor of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston. His interests include drug delivery and targeting, nanomedicine, multifunctional and stimuli-sensitive pharmaceutical nanocarriers, biomedical polymers, experimental cancer therapy. He has published more than 400 original papers, more than 150 reviews and book chapters, wrote and edited 12 books, and holds more than 40 patents. Google Scholar shows more than 44,000 citations of his papers with H-index of 96. He is Editor-in-Chief of Current Drug Discovery Technologies, Drug Delivery, and OpenNano, Co-Editor of Current Pharmaceutical Biotechnology and on the Editorial Boards of many other journals. He received more than $30 M from the governmental and industrial sources in research funding. He has multiple honors and awards and in 2011, Times Higher Education ranked him number 2 among top world scientists in pharmacology for the period of 2000-2010.


Prof. Mohamud Sheek Hussein

Epidemiology

UAE University

UAE

Dr Mohamud Sheek-Hussein is a physician specializing in international public health, epidemiology of infectious diseases and tropical medicine, currently an Associate Professor in the Institute of Public Health at the College of Medicine and Health Sciences at UAE University in Al Ain. Prior to joining UAE University, I was the Assistant Director and Head of Disease Control and Prevention, Epidemiology and Public Health Services of the Preventive Medicine Department of Al Ain Medical District under the Federal Ministry of Health, and lately Senior Communicable Disease Officer at the Abu Dhabi Health Authority, in the Eastern Region Al-Ain.

Dr Sheek-Hussein completed his Doctorate of Public Health in 2004 at the School of Public Health at the University of Texas in Houston (USA) where his dissertation focused on the epidemiological aspects of hepatitis C virus infection among pregnant women and neonates in the UAE. My main areas of research interest are infectious diseases, immunization and vaccine-preventable diseases, mother and child health, Viral Hepatitis C and B Virus, Liver Cancer, HIV/AIDS, Tuberculosis, and Malaria. During the past 25 years, Dr Sheek-Hussein has developed extensive practical and clinical experience of the health care system, public health services, and infectious disease surveillance in the UAE.


Prof. Payal Agarwal

Pharmaceutical Sciences

Notre Dame of Maryland University

USA

Dr. Payal Agarwal is an Associate Professor of Pharmaceutics in the School of Pharmacy at Notre Dame of Maryland University, Baltimore, MD. Dr. Agarwal currently teaches pharmaceutics, pharmaceutical calculations, and bio-pharmaceutics and clinical pharmacokinetics classes to first-year and second-year Pharm. D students. Her current research interests are oral delivery of protein- and peptide-based drugs through formulation of novel delivery systems.

            Thus far in her career she has received prestigious awards such as the Graduate Symposium Award from the American Association of Pharmaceutical Scientists (AAPS) and the Student Scholar Award from the American Association of Indian Pharmaceutical Scientists (AAiPS). She has also won the Innovation in Biotechnology Award, sponsored by Genentech and given by AAPS at the National Biotech Conference (NBC). She was also among the top five finalists for biotechnology section nominated by World Technology Network (WTN).  She has presented her research at several scientific conferences and has been a reviewer for many scientific manuscripts, new investigator award proposals, meeting abstracts, and book chapters. She is the author of Pharmaceutical Calculations textbook published by Jones and Bartlett Learning

Dr. Agarwal has been a member of Rho Chi Honor Society, AAPS, NBC, AAiPS American Diabetes Association (ADA) and American Association of Colleges of Pharmacy (AACP).  Dr. Agarwal received her PhD in pharmaceutical sciences from St. John’s University in New York, where she specialized in industrial pharmacy. She also holds a BS in pharmacy and MS in pharmaceutics from Dr. H. S. Gour University in Sagar, India.


Prof. Qaiser Jabeen

Pharmacy and Alternative Medicine

Islamia University of Bahawalpur

Pakistan

Research Publications:

  1. Gilani, A.H.; Aziz, N.; Khan, M.A.; Shaheen, F.; Jabeen, Q.; Siddiqui, B.S. and Herzig, J.W. (2000) Ethnopharmacological Evaluation of the Anticonvulsant, Sedative and Antispasmodic Activities of Lavandula stoechas. Journal of Ethnopharmacology, 71: 161-7.
  2. Gilani, A.H.; Jabeen, Q. and Khan, M. A. (2004) A Review of Medicinal Uses and Pharmacological Activities of Nigella sativa. Pakistan Journal of Biological Sciences, 7 (4): 441-51.
  3. Jabeen, Q.; Ghufran, A.; Khan, S.F.; Hotchand, A.; Gilani, A.H.; Ahmad, V.U.; Ahmed, A. and Rasheed, M. (2004) Ethnopharmacological Evaluation of Antispasmodic Activity of Essential Oils from Different Plants. Iranian Journal of Pharmaceutical Research, 3 (2): 44.                                         
  4. Jabeen, Q. and Rana, A. (2005) Newer Options in the Management of Hyperlipidemia. Heartbeat Online: 36-42.
  5. Gilani, A.H.; Jabeen, Q.; Ghayur, M.N.; Janbaz, K.H. and Akhtar, M.S. (2005) Studies on the Antihpertensive, Antispasmodic, Bronchodilator and Hepatoprotective activities of Carum copticum Seed Extract. Journal of Ethnopharmacology, 98: 127-35.                                                              
  6. Gilani, A.H.; Khan, A.; Shah, A.J.; Connor, J. and Jabeen, Q. (2005) Blood Pressure Lowering Effect of Olive is mediated through Calcium Channel blockade. International Journal of Food Sciences and Nutrition, 56 (8): 613-20.                                                                        
  7. Gilani, A.H.; Khan, A.; Jabeen, Q.; Subhan, S. and Ghafar, R. (2005) Antispasmodic and Blood Pressure Lowering Effects of Valeriana wallichi are mediated through K+ Channel Activation. Journal of Ethnopharmacology, 100: 347-52.                                                                                         
  8. Gilani, A.H.; Ghayur, M.N.; Houghton, P.J,; Jabeen Q.; Kazim, S.F.; Jumani,  M.I. and Saeed, S.A. (2006) Studies on the Hypotensive, Cardio-suppressant, Vasodilator and Antiplatelet Activities of Betel Nut Crude Extract and its Constituents. International Journal of Pharmacology, 2(1): 33-41.
  9. Bashir, S.; Janbaz, K.H.; Jabeen, Q. and Gilani, A.H. (2006) Studies on Spasmogenic and Spasmolytic Activities of Calendula officinalis flowers. Phytotherapy Research, 20: 906-10.
  10. Jabeen, Q.; Aziz, N.; Afzal, N. and Gilani, A.H. (2007) The Spasmogenic and Spasmolytic Activities of Lavandula stoechas are mediated through Muscarinic Receptor Stimulation and Calcium Channel Blockade. International Journal of Pharmacology, 3(1): 61-7.